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TargetLiver carboxylesterase 1
LigandBDBM195571
Substrate/Competitorn/a
Meas. Tech.Gel-based ABPP (CES1)
pH7.5±n/a
IC50<5±n/a nM
Commentsextracted
Citation Ahn, KBoehm, MBrown, MFCalloway, JChe, YChen, JFennell, KFGeoghegan, KFGilbert, AMGutierrez, JAKalgutkar, ASLanba, ALimberakis, CMagee, TVO'Doherty, IOliver, RPabst, BPandit, JParris, KPfefferkorn, JARolph, TPPatel, RSchuff, BShanmugasundaram, VStarr, JTVarghese, AHVera, NBVernochet, CYan, J Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism. ACS Chem Biol11:2529-40 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Liver carboxylesterase 1
Name:Liver carboxylesterase 1
Synonyms:Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1)
Type:Protein
Mol. Mass.:62520.83
Organism:Homo sapiens (Human)
Description:n/a
Residue:567
Sequence:
MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL
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BDBM195571
n/a
NameBDBM195571
Synonyms:(R)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1,2,3-triazol-4-yl)-[1,1'-biphenyl]-4-carboxylic acid (2)
TypeSmall organic molecule
Emp. Form.C27H24N4O3
Mol. Mass.452.5045
SMILESOC(=O)c1ccc(cc1)-c1ccc(cc1)-c1cnn(n1)C(=O)N1CCCC[C@@H]1c1ccccc1
Structure
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