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TargetIsocitrate dehydrogenase 2 (IDH2)
LigandBDBM195601
Substrate/Competitorn/a
Meas. Tech.Diaphorase/Resazurin Coupled Assay
Temperature298.15±n/a K
IC50 496±0.0 nM
Commentsextracted
Citation Okoye-Okafor UCBartholdy BCartier JGao ENPietrak BRendina ARRominger CQuinn CSmallwood AWiggall KJReif AJSchmidt SJQi HZhao HJoberty GFaelth-Savitski MBantscheff MDrewes GDuraiswami CBrady PGroy ANarayanagari SRAntony-Debre IMitchell KWang HRKao YRChristopeit MCarvajal LBarreyro LPaietta EMakishima HWill BConcha NAdams NDSchwartz BMcCabe MTMaciejewski JVerma ASteidl U New IDH1 mutant inhibitors for treatment of acute myeloid leukemia Nat Chem Biol 11:878-86 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Isocitrate dehydrogenase 2 (IDH2)
Name:Isocitrate dehydrogenase 2 (IDH2)
Synonyms:n/a
Type:Protein
Mol. Mass.:50923.31
Organism:Homo sapiens (Human)
Description:Full-length wild-type
Residue:452
Sequence:
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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  Blast E-value cutoff:
BDBM195601
n/a
NameBDBM195601
Synonyms:GSK321
TypeSmall organic molecule
Emp. Form.C28H28FN5O3
Mol. Mass.501.552
SMILESC[C@H](O)c1cccc(NC(=O)c2nn(Cc3ccc(F)cc3)c3[C@H](C)CN(Cc23)C(=O)c2ccc[nH]2)c1 |r|
Structure
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