| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 5D [1-775] |
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| Ligand | BDBM26113 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Demethylase AlphaScreen Assay |
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| pH | 7.5±n/a |
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| IC50 | 2.5e+3±n/a nM |
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| Comments | extracted |
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| Citation |  Johansson, C; Velupillai, S; Tumber, A; Szykowska, A; Hookway, ES; Nowak, RP; Strain-Damerell, C; Gileadi, C; Philpott, M; Burgess-Brown, N; Wu, N; Kopec, J; Nuzzi, A; Steuber, H; Egner, U; Badock, V; Munro, S; LaThangue, NB; Westaway, S; Brown, J; Athanasou, N; Prinjha, R; Brennan, PE; Oppermann, U Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol12:539-45 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 5D [1-775] |
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| Name: | Lysine-specific demethylase 5D [1-775] |
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| Synonyms: | HY | HYA | JARID1D | KDM5D | KDM5D_HUMAN | KIAA0234 | Lysine-specific demethylase 5D (KDM5D) | SMCY |
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| Type: | Protein |
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| Mol. Mass.: | 89076.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human KDM5D (1-775 aa) |
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| Residue: | 775 |
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| Sequence: | MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV
DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVI
EEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHP
FDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYG
PGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTM
QLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPK
CILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVS
SIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHI
NADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMK
MLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYN
FAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEM
FIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVC
LSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVED
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| BDBM26113 |
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| n/a |
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| Name | BDBM26113 |
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| Synonyms: | 2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | pyridine-2,4-dicarboxylic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C7H5NO4 |
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| Mol. Mass. | 167.1189 |
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| SMILES | OC(=O)c1ccnc(c1)C(O)=O |
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| Structure | 
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