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TargetLysine-specific demethylase 5A [1-801]
LigandBDBM191598
Substrate/Competitorn/a
Meas. Tech.Demethylase AlphaScreen Assay
pH7.5±n/a
IC50 7±n/a nM
Commentsextracted
Citation Johansson, CVelupillai, STumber, ASzykowska, AHookway, ESNowak, RPStrain-Damerell, CGileadi, CPhilpott, MBurgess-Brown, NWu, NKopec, JNuzzi, ASteuber, HEgner, UBadock, VMunro, SLaThangue, NBWestaway, SBrown, JAthanasou, NPrinjha, RBrennan, PEOppermann, U Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol12:539-45 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysine-specific demethylase 5A [1-801]
Name:Lysine-specific demethylase 5A [1-801]
Synonyms:JARID1A | KDM5A | KDM5A_HUMAN | Lysine-specific demethylase 5A (KDM5A) | RBBP2 | RBP2
Type:Protein
Mol. Mass.:91593.17
Organism:Homo sapiens (Human)
Description:Human KDM5A (1-801 aa)
Residue:801
Sequence:
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYAL
SKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQ
IFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCG
RGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVN
HYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLM
SEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDL
FRKLRDAVKEAETCASVAQLL
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  Blast E-value cutoff:
BDBM191598
n/a
NameBDBM191598
Synonyms:2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid (KDM5-C49) | KDM5-C49 | KDOAM-20
TypeSmall organic molecule
Emp. Form.C15H24N4O3
Mol. Mass.308.3761
SMILESCCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: