| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 5C [1-765] |
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| Ligand | BDBM195612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Demethylase AlphaScreen Assay |
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| pH | 7.5±n/a |
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| IC50 | 65±n/a nM |
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| Comments | extracted |
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| Citation |  Johansson, C; Velupillai, S; Tumber, A; Szykowska, A; Hookway, ES; Nowak, RP; Strain-Damerell, C; Gileadi, C; Philpott, M; Burgess-Brown, N; Wu, N; Kopec, J; Nuzzi, A; Steuber, H; Egner, U; Badock, V; Munro, S; LaThangue, NB; Westaway, S; Brown, J; Athanasou, N; Prinjha, R; Brennan, PE; Oppermann, U Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol12:539-45 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 5C [1-765] |
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| Name: | Lysine-specific demethylase 5C [1-765] |
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| Synonyms: | DXS1272E | JARID1C | KDM5C | KDM5C_HUMAN | Lysine-specific demethylase 5C (KDM5C) | SMCX | XE169 |
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| Type: | Protein |
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| Mol. Mass.: | 88156.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human KDM5C (1-765 aa) |
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| Residue: | 765 |
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| Sequence: | MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV
DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV
EEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP
FDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYG
AGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSH
SPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPE
IPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTEL
VEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMP
VLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSL
AAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRA
YHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDL
NLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALA
CYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKV
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| BDBM195612 |
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| n/a |
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| Name | BDBM195612 |
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| Synonyms: | GSK467 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13N5O2 |
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| Mol. Mass. | 319.3174 |
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| SMILES | O=c1[nH]c(Oc2cnn(Cc3ccccc3)c2)nc2cnccc12 |
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| Structure | 
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