| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase |
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| Ligand | BDBM196145 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 10000±n/a nM |
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| Comments | extracted |
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| Citation |  Ricciardi, RP Therapeutic compounds for blocking DNA synthesis of POX viruses US Patent US9211296 Publication Date 12/15/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase |
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| Name: | DNA polymerase |
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| Synonyms: | DNA Synthesis | DPOL_VACCW | OPG071 | POL |
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| Type: | Enzyme |
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| Mol. Mass.: | 116939.47 |
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| Organism: | Vaccinia virus (strain WR) |
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| Description: | P06856 |
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| Residue: | 1006 |
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| Sequence: | MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQSLSPPPFNARPL
GKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSIQNATMDEFLNISWFYISNGIS
PDGCYSLDEQYLTKINNGCYHCDDPRNCFAKKIPRFDIPRSYLFLDIECHFDKKFPSVFI
NPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCS
EIVLLRIAKQLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVYLCIY
ERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFSCMGKV
LNRGVREMTFIGDDTTDAKGKAAAFAKVLTTGNYVTVDEDIICKVIRKDIWENGFKVVLL
CPTLPNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARYCIHDACLCQYLWEYYGVETKTD
AGASTYVLPQSMVFEYRASTVIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKM
FSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITVH
CEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDSMQYTY
KIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGAELSNGMLRFANPLSN
PFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSVFTEIDSQDVDKSIEIAKELERLINN
RVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHK
NMIKTYKTRLSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSNY
KSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDRSFKL
GSDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSKPTFYEA
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| BDBM196145 |
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| n/a |
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| Name | BDBM196145 |
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| Synonyms: | US9211296, Table 7, Compd: 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20ClN3OS |
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| Mol. Mass. | 373.9 |
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| SMILES | Clc1nc2ccccc2c2sc(cc12)C(=O)NCCCN1CCCC1 |
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| Structure | 
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