Ki Summary

Reaction Details

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Target

Histone deacetylase 6 [440-798,S531A]

Ligand

BDBM198125

Substrate/Competitor

n/a

Meas. Tech.

HDAC6 fluorescence anisotropy assay

Temperature

298.15±n/a K

170±40 nM

Comments

extracted

Citation

Hai, Y; University of Pennsylvania,, DW Histone deacetylase 6 structure and molecular basis of catalysis and inhibition Nat Chem Biol12:741-747 (2016) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Histone deacetylase 6 [440-798,S531A]

Name:

Histone deacetylase 6 [440-798,S531A]

Synonyms:

Catalytic domain 2 S531A (zCD2 S531A) | zCD2 S531A

Type:

n/a

Mol. Mass.:

39834.25

Organism:

Danio rerio

Description:

F8W4B7[440-798,S531A]

Residue:

359

Sequence:

SSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEEL
ALCHSSKHISIIKSSEHMKPRDLNRLGDEYNAIFISNESYTCALLAAGSCFNSAQAILTG
QVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGT
QHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYM
AAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLI
ILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR

BDBM198125

n/a

Name

BDBM198125

Synonyms:

fl-SAHA

Type

Small organic molecule

Emp. Form.

C28H26N2O8

Mol. Mass.

518.5146

SMILES

ONC(=O)CCCCCCC(=O)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12 |(29.64,-15.16,;28.31,-15.93,;26.97,-15.16,;26.97,-13.62,;25.64,-15.93,;24.31,-15.16,;22.97,-15.93,;21.64,-15.16,;20.31,-15.93,;18.97,-15.16,;17.64,-15.93,;17.64,-17.47,;16.3,-15.16,;14.97,-15.93,;13.64,-15.16,;12.3,-15.93,;12.3,-17.47,;13.64,-18.24,;14.97,-17.47,;14.41,-19.57,;15.95,-19.57,;13.64,-20.9,;10.97,-18.24,;9.64,-17.47,;9.64,-15.93,;8.3,-15.16,;6.97,-15.93,;5.48,-15.53,;6.97,-17.47,;8.3,-18.24,;8.3,-19.78,;9.64,-20.55,;9.64,-22.09,;10.97,-22.86,;10.97,-24.4,;12.3,-22.09,;12.3,-20.55,;10.97,-19.78,)|

Structure