| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 6 [440-798] |
|---|
| Ligand | BDBM198120 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | HDAC6 fluorescence anisotropy assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | 0.8±0.1 nM |
|---|
| IC50 | 1.4±0.2 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Hai, Y; University of Pennsylvania,, DW Histone deacetylase 6 structure and molecular basis of catalysis and inhibition Nat Chem Biol12:741-747 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 6 [440-798] |
|---|
| Name: | Histone deacetylase 6 [440-798] |
|---|
| Synonyms: | Catalytic domain 2 (zCD2) | zCD2 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 39850.25 |
|---|
| Organism: | Danio rerio |
|---|
| Description: | F8W4B7[440-798] |
|---|
| Residue: | 359 |
|---|
| Sequence: | SSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEEL
ALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTG
QVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGT
QHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYM
AAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLI
ILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
|
|
|
|---|
| BDBM198120 |
|---|
| n/a |
|---|
| Name | BDBM198120 |
|---|
| Synonyms: | TSA |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H22N2O3 |
|---|
| Mol. Mass. | 302.3682 |
|---|
| SMILES | CC(\C=C\C(=O)NO)\C=C(/C)C(=O)c1ccc(cc1)N(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
