| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 6 [440-798] |
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| Ligand | BDBM50123957 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC6 fluorescence anisotropy assay |
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| Temperature | 298.15±n/a K |
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| Ki | 4.3±0.5 nM |
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| IC50 | 7.5±0.9 nM |
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| Comments | extracted |
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| Citation |  Hai, Y; University of Pennsylvania,, DW Histone deacetylase 6 structure and molecular basis of catalysis and inhibition Nat Chem Biol12:741-747 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Histone deacetylase 6 [440-798] |
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| Name: | Histone deacetylase 6 [440-798] |
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| Synonyms: | Catalytic domain 2 (zCD2) | zCD2 |
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| Type: | n/a |
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| Mol. Mass.: | 39850.25 |
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| Organism: | Danio rerio |
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| Description: | F8W4B7[440-798] |
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| Residue: | 359 |
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| Sequence: | SSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEEL
ALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTG
QVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGT
QHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYM
AAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLI
ILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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| BDBM50123957 |
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| n/a |
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| Name | BDBM50123957 |
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| Synonyms: | (E)-5-(3-Benzenesulfonylamino-phenyl)-pent-2-en-4-ynoic acid hydroxyamide | (E)-5-(4-Benzenesulfonylamino-phenyl)-pent-2-en-4-ynoic acid hydroxyamide | 5-(4-Benzenesulfonylamino-phenyl)-pent-2-en-4-ynoic acid hydroxyamide | CHEMBL314389 | Oxamflatin |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14N2O4S |
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| Mol. Mass. | 342.369 |
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| SMILES | ONC(=O)\C=C\C#Cc1ccc(NS(=O)(=O)c2ccccc2)cc1 |
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| Structure | 
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