| Reaction Details |
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 | Report a problem with these data |
| Target | Flap endonuclease 1 [1-336] |
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| Ligand | BDBM50157840 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Steady-State Kinetics |
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| pH | 7.5±n/a |
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| IC50 | 46.4±4.8 nM |
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| Comments | extracted |
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| Citation |  Exell, JC; Thompson, MJ; Finger, LD; Shaw, SJ; Debreczeni, J; Ward, TA; McWhirter, C; Siöberg, CL; Martinez Molina, D; Abbott, WM; Jones, CD; Nissink, JW; Durant, ST; Grasby, JA Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol12:815-21 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Flap endonuclease 1 [1-336] |
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| Name: | Flap endonuclease 1 [1-336] |
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| Synonyms: | FEN1 | FEN1_HUMAN | Flap endonuclease 1 (aa 1-336) | RAD2 |
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| Type: | Protein |
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| Mol. Mass.: | 37858.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | C-terminally truncated after residue 336 |
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| Residue: | 336 |
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| Sequence: | MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGST
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| BDBM50157840 |
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| n/a |
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| Name | BDBM50157840 |
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| Synonyms: | 1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1) | 1-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-hydroxy-1H-thieno[3,2-d]pyrimidine-2,4-dione | CHEMBL361546 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N2O5S |
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| Mol. Mass. | 332.331 |
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| SMILES | On1c(=O)n(CC2COc3ccccc3O2)c2ccsc2c1=O |
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| Structure | 
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