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TargetFlap endonuclease 1 (hFEN1-336Δ)
LigandBDBM197162
Substrate/Competitorn/a
Meas. Tech.Steady-State Kinetics
pH7.5±n/a
IC50 16.9±1.2 nM
Commentsextracted
Citation Exell JCThompson MJFinger LDShaw SJDebreczeni JWard TAMcWhirter CSi÷berg CLMartinez Molina DAbbott WMJones CDNissink JWDurant STGrasby JA Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol 12:815-21 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Flap endonuclease 1 (hFEN1-336Δ)
Name:Flap endonuclease 1 (hFEN1-336Δ)
Synonyms:n/a
Type:Protein
Mol. Mass.:37858.07
Organism:Homo sapiens (Human)
Description:C-terminally truncated after residue 336
Residue:336
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGST
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  Blast E-value cutoff:
BDBM197162
n/a
NameBDBM197162
Synonyms:3-hydroxy-1-(4-methoxybenzyl)quinazoline-2,4(1H,3H)-dione (4)
TypeSmall organic molecule
Emp. Form.C16H14N2O4
Mol. Mass.298.2934
SMILESCOc1ccc(Cn2c3ccccc3c(=O)n(O)c2=O)cc1
Structure
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