| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 6 [25-831] |
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| Ligand | BDBM197337 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC activity assays |
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| IC50 | 9.88±1.01 nM |
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| Citation |  Miyake, Y; Keusch, JJ; Wang, L; Saito, M; Hess, D; Wang, X; Melancon, BJ; Helquist, P; Gut, H; Matthias, P Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat Chem Biol12:748-54 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 6 [25-831] |
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| Name: | Histone deacetylase 6 [25-831] |
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| Synonyms: | HDAC6 (CD1-CD2) |
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| Type: | n/a |
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| Mol. Mass.: | 89087.42 |
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| Organism: | Danio rerio (Zebrafish) |
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| Description: | F8W4B7 25-831 aa |
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| Residue: | 807 |
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| Sequence: | KNLQEARRKGRMDRSKAEEEMSNELQNLDVQGKSKATGTGLVYVDAFTRFHCLWDASHPE
CPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLLVHTKEYVELMKSTQNMTEEELKTL
AEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPGHHAQADKMNGFCM
FNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHL
KESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDA
VIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSLLGDPC
PHLPSSGAPCESALKSISKTISDLYPFWKSLQTFEGGPLSEVSPLPAPVCAEVKVSSPIT
GLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHS
SKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNA
VAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFE
EDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHH
LVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGG
YNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLRVNIPES
LRLSLPSPKPKGKCTPGGKGKKSPRQS
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| BDBM197337 |
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| n/a |
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| Name | BDBM197337 |
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| Synonyms: | S-TSA |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22N2O3 |
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| Mol. Mass. | 302.3682 |
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| SMILES | C[C@@H](\C=C\C(=O)NO)\C=C(/C)C(=O)c1ccc(cc1)N(C)C |r| |
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| Structure | 
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