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TargetComplement factor B
LigandBDBM159312
Substrate/Competitorn/a
Meas. Tech.Human Complement Factor B TR-FRET Assay
IC50 0.02±n/a nM
Citation Adams, CMCapparelli, MPEhara, TKarki, RGMainolfi, NZhang, C Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof US Patent US9682968 Publication Date 6/20/2017
More Info.:Get all data from this article,  Assay Method
 
Complement factor B
Name:Complement factor B
Synonyms:BF | BFD | CFAB_HUMAN | CFB
Type:Enzyme
Mol. Mass.:85537.97
Organism:Homo sapiens (Human)
Description:P00751
Residue:764
Sequence:
MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM159312
n/a
NameBDBM159312
Synonyms:US10093663, Example 17-1 | US9682968, Example-17-1
TypeSmall organic molecule
Emp. Form.C25H28N2O2
Mol. Mass.388.502
SMILESCc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(cc2)C(O)=O)c2cc[nH]c12 |r|
Structure
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