| Reaction Details |
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 | Report a problem with these data |
| Target | Complement factor B |
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| Ligand | BDBM160474 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human Complement Factor B TR-FRET Assay |
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| IC50 | 0.05±n/a nM |
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| Citation |  Adams, CM; Capparelli, MP; Ehara, T; Karki, RG; Mainolfi, N; Zhang, C Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof US Patent US9682968 Publication Date 6/20/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Complement factor B |
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| Name: | Complement factor B |
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| Synonyms: | BF | BFD | CFAB_HUMAN | CFB |
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| Type: | Enzyme |
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| Mol. Mass.: | 85537.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00751 |
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| Residue: | 764 |
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| Sequence: | MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
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| BDBM160474 |
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| n/a |
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| Name | BDBM160474 |
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| Synonyms: | US9682968, Example-25b (-) |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26N2O2 |
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| Mol. Mass. | 362.4647 |
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| SMILES | Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)C(O)=O |
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| Structure | 
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