| Reaction Details |
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 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
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| Ligand | BDBM199122 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | enzyme-based fluorimetric assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 123.4±0.36 nM |
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| Comments | extracted |
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| Citation |  Zheng, XZ; Zhou, JL; Ye, J; Guo, PP; Lin, CS Cardioprotective effect of novel sulphonamides-1,3,5-triazine conjugates against ischaemic-reperfusion injury via selective inhibition of MMP-9. Chem Biol Drug Des88:756-765 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 72 kDa type IV collagenase |
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| Name: | 72 kDa type IV collagenase |
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| Synonyms: | 72 kDa type IV collagenase | MMP2_RAT | Matrix metalloproteinase-2 (MMP-2) | Mmp2 |
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| Type: | n/a |
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| Mol. Mass.: | 74137.51 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P33436 |
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| Residue: | 662 |
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| Sequence: | MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGT
SYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGI
AQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGN
EYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKM
DPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWL
GC
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| BDBM199122 |
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| n/a |
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| Name | BDBM199122 |
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| Synonyms: | N-(4-(1-(4,6-bis(phenylamino)-1,3,5-triazin-2-yl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)phenyl)-4-methylbenzenesulphonamide (8d) |
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| Type | Small organic molecule |
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| Emp. Form. | C38H32N8O3S |
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| Mol. Mass. | 680.777 |
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| SMILES | COc1ccc(cc1)-c1cc(nn1-c1nc(Nc2ccccc2)nc(Nc2ccccc2)n1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1 |
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| Structure | 
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