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TargetTyrosine--tRNA ligase
LigandBDBM199138
Substrate/Competitorn/a
Meas. Tech.In vitro Enzyme Inhibition Assay
pH7.9±n/a
IC50 3.667e+4± 4.5e+2 nM
Commentsextracted
Citation Chen, LWWang, PFTang, DJTao, XXMan, RJQiu, HYWang, ZCXu, CZhu, HL Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation. Chem Biol Drug Des88:592-8 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine--tRNA ligase
Name:Tyrosine--tRNA ligase
Synonyms:SYY_STAAS | Tyrosyl-tRNA synthetase | tyrS
Type:Protein
Mol. Mass.:47586.43
Organism:Staphylococcus aureus (strain MSSA476)
Description:n/a
Residue:420
Sequence:
MTNVLIEDLKWRGLIYQQTDEQGIEDLLNKEQVTLYCGADPTADSLHIGHLLPFLTLRRF
QEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTEEQVDKNIEGISKQMHNIFEFGTDHGAV
LVNNRDWLGQISLISFLRDYGKHVGVNYMLGKDSIQSRLEHGISYTEFTYTILQAIDFGH
LNRELNCKIQVGGSDQWGNITSGIELMRRMYGQTDAYGLTIPLVTKSDGKKFGKSESGAV
WLDAEKTSPYEFYQFWINQSDEDVIKFLKYFTFLGKEEIDRLEQSKNEAPHLREAQKTLA
EEVTKFIHGEDALNDAIRISQALFSGDLKSLSAKELKDGFKDVPQVTLSNDTTNIVEVLI
ETGISPSKRQAREDVNNGAIYINGERQQDVNYALAPEDKIDGEFTIIRRGKKKYFMVNYQ
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  Blast E-value cutoff:
BDBM199138
n/a
NameBDBM199138
Synonyms:2-(2-Methyl-5-nitro-1H-imidazol-1-yl)-ethyl-5-(4-iodophenyl)-1-phenyl-1H-pyrazole-3-carboxylate (4j)
TypeSmall organic molecule
Emp. Form.C22H18IN5O4
Mol. Mass.543.3139
SMILESCc1ncc(n1CCOC(=O)c1cc(-c2ccc(I)cc2)n(n1)-c1ccccc1)[N+]([O-])=O
Structure
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