Reaction Details |
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Target | Tyrosine--tRNA ligase |
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Ligand | BDBM199138 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In vitro Enzyme Inhibition Assay |
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pH | 7.9±n/a |
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IC50 | 3.667e+4± 4.5e+2 nM |
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Comments | extracted |
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Citation | Chen, LW; Wang, PF; Tang, DJ; Tao, XX; Man, RJ; Qiu, HY; Wang, ZC; Xu, C; Zhu, HL Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation. Chem Biol Drug Des88:592-8 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine--tRNA ligase |
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Name: | Tyrosine--tRNA ligase |
Synonyms: | SYY_STAAS | Tyrosyl-tRNA synthetase | tyrS |
Type: | Protein |
Mol. Mass.: | 47586.43 |
Organism: | Staphylococcus aureus (strain MSSA476) |
Description: | n/a |
Residue: | 420 |
Sequence: | MTNVLIEDLKWRGLIYQQTDEQGIEDLLNKEQVTLYCGADPTADSLHIGHLLPFLTLRRF
QEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTEEQVDKNIEGISKQMHNIFEFGTDHGAV
LVNNRDWLGQISLISFLRDYGKHVGVNYMLGKDSIQSRLEHGISYTEFTYTILQAIDFGH
LNRELNCKIQVGGSDQWGNITSGIELMRRMYGQTDAYGLTIPLVTKSDGKKFGKSESGAV
WLDAEKTSPYEFYQFWINQSDEDVIKFLKYFTFLGKEEIDRLEQSKNEAPHLREAQKTLA
EEVTKFIHGEDALNDAIRISQALFSGDLKSLSAKELKDGFKDVPQVTLSNDTTNIVEVLI
ETGISPSKRQAREDVNNGAIYINGERQQDVNYALAPEDKIDGEFTIIRRGKKKYFMVNYQ
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BDBM199138 |
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n/a |
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Name | BDBM199138 |
Synonyms: | 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)-ethyl-5-(4-iodophenyl)-1-phenyl-1H-pyrazole-3-carboxylate (4j) |
Type | Small organic molecule |
Emp. Form. | C22H18IN5O4 |
Mol. Mass. | 543.3139 |
SMILES | Cc1ncc(n1CCOC(=O)c1cc(-c2ccc(I)cc2)n(n1)-c1ccccc1)[N+]([O-])=O |
Structure |
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