| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM199227 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Endothelial Lipase Assay |
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| pH | 7.2±n/a |
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| IC50 | 1195±n/a nM |
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| Comments | extracted |
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| Citation |  Connelly, MA; Greco, M; Ye, H Tricyclic indole derivatives useful endothelial lipase inhibitors US Patent US9216998 Publication Date 12/22/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | Endothelial cell-derived lipase | Endothelial lipase | Endothelial lipase (EL) | LIPE_MOUSE | Lipg |
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| Type: | Protein |
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| Mol. Mass.: | 56643.58 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q9WVG5 |
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| Residue: | 500 |
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| Sequence: | MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPE
QEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHID
IYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
SRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNN
SGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVA
HSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWF
HKCQDGWKMKNKTSPFVNLA
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|
|
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| BDBM199227 |
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| n/a |
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| Name | BDBM199227 |
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| Synonyms: | US9216998, 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22F3N |
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| Mol. Mass. | 357.412 |
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| SMILES | FC(F)(F)c1c(CCCc2ccccc2)n2CCCCc3cccc1c23 |
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| Structure | 
|
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