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TargetMitogen-activated protein kinase 1
LigandBDBM199569
Substrate/Competitorn/a
Meas. Tech.IMAP-FP Assay
IC50 0.5±n/a nM
Citation Wilson, KJWitter, DJDaniels, MHAngeles, ARSiliphaivanh, PSloman, DO'Boyle, BFalcone, DWhite, CFerguson, RZhou, WLipford, KMansoor, UFFevrier, SHuang, XKurukulasuriya, RRichard, JETang, SBoyce, CKozlowski, JBakshi, RKKarunakaran, GB Compounds that are ERK inhibitors US Patent US9226922 Publication Date 1/5/2016
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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  Blast E-value cutoff:
BDBM199569
n/a
NameBDBM199569
Synonyms:US9226922, 205
TypeSmall organic molecule
Emp. Form.C20H25N5O5
Mol. Mass.415.443
SMILESCC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(OCCO)c2c(CO)n1)c1ccccc1 |r|
Structure
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