| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 1 of Metabotropic glutamate receptor 5 (5a) |
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| Ligand | BDBM199986 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| pH | 7.4±n/a |
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| Ki | 315±0.0 nM |
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| Comments | extracted |
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| Citation |  Jaeschke, G; Lindemann, L; Ricci, A; Rueher, D; Stadler, H; Vieira, E Ethynyl derivatives US Patent US9227959 Publication Date 1/5/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 1 of Metabotropic glutamate receptor 5 (5a) |
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| Name: | Isoform 1 of Metabotropic glutamate receptor 5 (5a) |
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| Synonyms: | GPRC1E | GRM5 | GRM5_HUMAN | MGLUR5 | Metabotropic glutamate receptor 5 | Metabotropic glutamate receptor 5 (5a) | Metabotropic glutamate receptor 5 (mGlu5a) | Metabotropic glutamate receptor 5 (mGluR5a) | Metabotropic glutamate receptor 5a (mGluR5) | Metabotropic glutamate receptor 5a (mGluR5a) | Metabotropic glutamate receptor subtype 5 (mGluR5) |
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| Type: | Enzyme |
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| Mol. Mass.: | 128885.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41594-2 |
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| Residue: | 1180 |
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| Sequence: | MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAV
REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS
EEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLS
DKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGI
CIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFL
LLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQ
HRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP
GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD
YINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKEN
EYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVV
FIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYS
ALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIM
HDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYT
TCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS
TVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLSSNGKSVTWAQNEKSSRGQHLWQR
LSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPES
PDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSS
SQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTF
AEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDS
VDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL
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| BDBM199986 |
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| n/a |
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| Name | BDBM199986 |
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| Synonyms: | US9227959, Reference Compound 2, Ex. 46 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3O |
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| Mol. Mass. | 319.4002 |
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| SMILES | CC1(C)CCCN(C1)C(=O)c1ncc(cn1)C#Cc1ccccc1 |
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| Structure | 
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