Reaction Details |
| Report a problem with these data |
Target | Kallikrein-1 |
---|
Ligand | BDBM200016 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In Vitro Inhibition Assay |
---|
IC50 | >1000±n/a nM |
---|
Citation | Evans, DM; Davie, RL; Edwards, HJ; Rooker, DP Benzylamine derivatives as inhibitors of plasma kallikrein US Patent US9234000 Publication Date 1/12/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Kallikrein-1 |
---|
Name: | Kallikrein-1 |
Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
Type: | Enzyme |
Mol. Mass.: | 28874.69 |
Organism: | Homo sapiens (Human) |
Description: | P06870 |
Residue: | 262 |
Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
|
|
|
BDBM200016 |
---|
n/a |
---|
Name | BDBM200016 |
Synonyms: | US9234000, 7 |
Type | Small organic molecule |
Emp. Form. | C31H37FN4O4 |
Mol. Mass. | 548.6483 |
SMILES | CCOc1ccc(CC(=O)CNN([C@@H](Cc2ccccc2)C(=O)NCc2ccc(CN)c(F)c2)C(=O)CC)cc1 |
Structure |
|