| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B10 |
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| Ligand | BDBM50029207 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IC50-Activity Assay (AKR1B10) |
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| pH | 7±n/a |
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| IC50 | 80±n/a nM |
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| Comments | extracted |
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| Citation |  Cousido-Siah, A; Ruiz, FX; Franflík, J; Giménez-Dejoz, J; Mitschler, A; Kamlar, M; Vesely´, J; Ajani, H; Parés, X; Farrés, J; Hobza, P; Podjarny, AD IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors ACS Chem Biol11:2693-2705 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B10 |
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| Name: | Aldo-keto reductase family 1 member B10 |
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| Synonyms: | AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP |
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| Type: | Protein |
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| Mol. Mass.: | 36024.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60218. 1ZUA; 4JII; 4GQ0 |
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| Residue: | 316 |
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| Sequence: | MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ
EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD
DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
VLQSSHLEDYPFNAEY
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| BDBM50029207 |
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| n/a |
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| Name | BDBM50029207 |
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| Synonyms: | (E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethyl ester | (E)-phenethyl 3-(3,4-dihydroxyphenyl)acrylate | 3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethyl ester | CAPE | CHEMBL319244 | caffeic acid phenethyl ester | caffeic acid phenethylester | caffeic acid phenylethyl ester | caffeic acid phenylethylester | caffeic acidphenethylester | phenethyl 3-(3,4-dihydroxyphenyl)acrylate | phenethyl caffeate |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16O4 |
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| Mol. Mass. | 284.3065 |
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| SMILES | Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O |
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| Structure | 
|
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