Reaction Details | |||
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Target | Cystic fibrosis transmembrane conductance regulator | ||
Ligand | BDBM50139181 | ||
Substrate/Competitor | n/a | ||
EC50 | >50000±n/a nM | ||
Citation | PubChem, PC Phenotypic Assay to Identify Small Molecules that Upregulate Production of hCFTR in HeLa Cells PubChem Bioassay(2016)[AID] | ||
More Info.: | Get all data from this article | ||
Cystic fibrosis transmembrane conductance regulator | |||
Name: | Cystic fibrosis transmembrane conductance regulator | ||
Synonyms: | ABCC7 | ATP-binding cassette sub-family C member 7 | CFTR | CFTR_HUMAN | Channel conductance-controlling ATPase | cAMP-dependent chloride channel | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 168171.30 | ||
Organism: | Homo sapiens (Human) | ||
Description: | gi_90421313 | ||
Residue: | 1480 | ||
Sequence: |
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BDBM50139181 | |||
n/a | |||
Name | BDBM50139181 | ||
Synonyms: | (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate | 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one | MK-733 | SIMVASTATIN LACTONE | Simvastatin | Zocor | cid_54454 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H38O5 | ||
Mol. Mass. | 418.5662 | ||
SMILES | CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 |r,c:14,t:12| | ||
Structure |