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TargetProprotein convertase subtilisin/kexin type 9
LigandBDBM200328
Substrate/Competitorn/a
Meas. Tech.AlphaLISA Assay
IC50 2300±n/a nM
Citation Darout, EDullea, RHawkins, JJLondregan, ATLoria, PMMaguire, BMcClure, KFPetersen, DNPiotrowski, DW Substituted amide compounds US Patent US9227956 Publication Date 1/5/2016
More Info.:Get all data from this article,  Assay Method
 
Proprotein convertase subtilisin/kexin type 9
Name:Proprotein convertase subtilisin/kexin type 9
Synonyms:NARC-1 | NARC1 | Neural apoptosis-regulated convertase 1 | PC9 | PCSK9 | PCSK9_HUMAN | Proprotein convertase 9 | Proprotein convertase subtilisin/kexin type 9 | Proprotein convertase subtilisin/kexin type 9 (PCSK9) | Subtilisin/kexin type 9 | Subtilisin/kexin-like protease PC9
Type:Enzyme
Mol. Mass.:74286.93
Organism:Homo sapiens (Human)
Description:Q8NBP7
Residue:692
Sequence:
MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGT
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLP
GFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV
EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAG
VAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA
CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVD
LFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA
KDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPD
EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAP
PAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASC
CHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRD
VSTTGSTSEGAVTAVAICCRSRHLAQASQELQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM200328
n/a
NameBDBM200328
Synonyms:US9227956, 13
TypeSmall organic molecule
Emp. Form.C24H27N5O3
Mol. Mass.433.5029
SMILESCOC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Structure
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