Reaction Details |
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Target | Proprotein convertase subtilisin/kexin type 9 |
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Ligand | BDBM200327 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Cell Free Assay |
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IC50 | 1700±n/a nM |
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Citation | Darout, E; Dullea, R; Hawkins, JJ; Londregan, AT; Loria, PM; Maguire, B; McClure, KF; Petersen, DN; Piotrowski, DW Substituted amide compounds US Patent US9227956 Publication Date 1/5/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Proprotein convertase subtilisin/kexin type 9 |
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Name: | Proprotein convertase subtilisin/kexin type 9 |
Synonyms: | NARC-1 | NARC1 | Neural apoptosis-regulated convertase 1 | PC9 | PCSK9 | PCSK9_HUMAN | Proprotein convertase 9 | Proprotein convertase subtilisin/kexin type 9 | Proprotein convertase subtilisin/kexin type 9 (PCSK9) | Subtilisin/kexin type 9 | Subtilisin/kexin-like protease PC9 |
Type: | Enzyme |
Mol. Mass.: | 74286.93 |
Organism: | Homo sapiens (Human) |
Description: | Q8NBP7 |
Residue: | 692 |
Sequence: | MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGT
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLP
GFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV
EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAG
VAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA
CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVD
LFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA
KDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPD
EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAP
PAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASC
CHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRD
VSTTGSTSEGAVTAVAICCRSRHLAQASQELQ
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BDBM200327 |
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n/a |
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Name | BDBM200327 |
Synonyms: | US9227956, 12 |
Type | Small organic molecule |
Emp. Form. | C25H26N6O3 |
Mol. Mass. | 458.5123 |
SMILES | Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12 |r| |
Structure |
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