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TargetMuscarinic acetylcholine receptor M3
LigandBDBM200754
Substrate/Competitorn/a
Meas. Tech.Muscarinic Receptor Binding Assay
IC50 0.8±n/a nM
Citation Aiguade Bosch, JGual Roig, SPrat Quinones, MPuig Duran, C Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities US Patent US9233108 Publication Date 1/12/2016
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M3
Name:Muscarinic acetylcholine receptor M3
Synonyms:ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:Enzyme
Mol. Mass.:66151.03
Organism:Homo sapiens (Human)
Description:P20309
Residue:590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
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  Blast E-value cutoff:
BDBM200754
n/a
NameBDBM200754
Synonyms:US9233108, 19 | US9757383, Example 19
TypeSmall organic molecule
Emp. Form.C40H44N4O8S2
Mol. Mass.772.929
SMILESCN(CCCn1c2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2oc1=O)[C@H]1CC[C@@H](CC1)OC(=O)C(O)(c1cccs1)c1cccs1 |wU:36.43,wD:14.14,33.36,(5.47,2.57,;6.5,3.72,;8,3.4,;8.48,1.93,;9.98,1.61,;10.46,.15,;11.93,-.33,;13.26,.44,;14.59,-.33,;14.59,-1.87,;15.93,-2.64,;15.93,-4.18,;17.26,-4.95,;17.26,-6.49,;18.59,-7.26,;19.93,-6.49,;18.59,-8.8,;17.26,-9.57,;17.26,-11.11,;18.59,-11.88,;18.59,-13.42,;19.93,-11.11,;21.26,-11.88,;22.59,-11.11,;23.93,-11.88,;22.59,-9.57,;21.26,-8.8,;19.93,-9.57,;13.26,-2.64,;11.93,-1.87,;10.46,-2.34,;9.56,-1.1,;8.02,-1.1,;6.02,5.18,;7.05,6.33,;6.57,7.79,;5.07,8.11,;4.04,6.97,;4.51,5.5,;4.59,9.58,;3.09,9.9,;2.06,8.75,;2.61,11.36,;4.07,11.84,;2.13,12.83,;.67,13.3,;.67,14.84,;2.13,15.32,;3.04,14.07,;1.15,10.89,;.67,9.42,;-.87,9.42,;-1.35,10.89,;-.1,11.79,)|
Structure
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