Reaction Details |
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Target | Potassium channel subfamily K member 2 |
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Ligand | BDBM50117922 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TREK1 Assay |
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pH | 7.3±n/a |
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Temperature | 295.15±n/a K |
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EC50 | 500±n/a nM |
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Comments | extracted |
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Citation | Viswanath, AN; Jung, SY; Hwang, EM; Park, KD; Lim, SM; Min, SJ; Cho, YS; Pae, AN Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently. Chem Biol Drug Des88:807-819 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium channel subfamily K member 2 |
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Name: | Potassium channel subfamily K member 2 |
Synonyms: | KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1 |
Type: | Protein |
Mol. Mass.: | 47099.16 |
Organism: | Homo sapiens (Human) |
Description: | O95069 |
Residue: | 426 |
Sequence: | MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK
TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ
IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL
GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL
PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA
VIENIK
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BDBM50117922 |
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n/a |
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Name | BDBM50117922 |
Synonyms: | (1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl 2-methoxyacetate | 2-{2-[3-(1H-benzoimidazol-2-yl)-propylamino]-ethyl}-6-fluoro-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester(Mibefradil)Methoxy-acetic acid | CHEMBL45816 | MIBEFRADIL | Methoxy-acetic acid (1S,2S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester | Methoxy-acetic acid 2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester | Mibefradil dihydrochloride |
Type | Small organic molecule |
Emp. Form. | C29H38FN3O3 |
Mol. Mass. | 495.6287 |
SMILES | COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C |r| |
Structure |
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