Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPotassium channel subfamily K member 2
LigandBDBM50408507
Substrate/Competitorn/a
Meas. Tech.TREK1 Assay
pH7.3±n/a
Temperature295.15±n/a K
EC50 2700±n/a nM
Commentsextracted
Citation Viswanath, ANJung, SYHwang, EMPark, KDLim, SMMin, SJCho, YSPae, AN Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently. Chem Biol Drug Des88:807-819 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium channel subfamily K member 2
Name:Potassium channel subfamily K member 2
Synonyms:KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1
Type:Protein
Mol. Mass.:47099.16
Organism:Homo sapiens (Human)
Description:O95069
Residue:426
Sequence:
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK
TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ
IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL
GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL
PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA
VIENIK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50408507
n/a
NameBDBM50408507
Synonyms:CHLOROPROMAZINE SULFOXIDE | Chlorpromazine sulfoxide
TypeSmall organic molecule
Emp. Form.C17H19ClN2OS
Mol. Mass.334.864
SMILESCN(C)CCCN1c2ccccc2S(=O)c2ccc(Cl)cc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: