| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 2 |
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| Ligand | BDBM50066430 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TREK1 Assay |
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| pH | 7.3±n/a |
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| Temperature | 295.15±n/a K |
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| EC50 | 4000±n/a nM |
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| Comments | extracted |
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| Citation |  Viswanath, AN; Jung, SY; Hwang, EM; Park, KD; Lim, SM; Min, SJ; Cho, YS; Pae, AN Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently. Chem Biol Drug Des88:807-819 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 2 |
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| Name: | Potassium channel subfamily K member 2 |
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| Synonyms: | KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1 |
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| Type: | Protein |
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| Mol. Mass.: | 47099.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O95069 |
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| Residue: | 426 |
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| Sequence: | MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK
TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ
IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL
GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL
PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA
VIENIK
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| BDBM50066430 |
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| n/a |
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| Name | BDBM50066430 |
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| Synonyms: | 2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phenyl)-pyrimidin-4-ylamine | 2-(4-Methyl-piperazin-1-yl)-5-(2,3,5-trichloro-phenyl)-pyrimidin-4-ylamine(BW619C89) | CHEMBL28854 | SIPATRIGINE |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16Cl3N5 |
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| Mol. Mass. | 372.68 |
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| SMILES | CN1CCN(CC1)c1ncc(c(N)n1)-c1cc(Cl)cc(Cl)c1Cl |
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| Structure | 
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