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TargetMitogen-activated protein kinase 12
LigandBDBM142598
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibition Assay
Temperature298.15±n/a K
IC50 344±0.0 nM
Commentsextracted
Citation Ito, K; Strong, P; Rapeport, WG; Murray, PJ; King-Underwood, J; Williams, JG; Onions, S; Charron, CE P38MAP kinase inhibitors US Patent US9242960 Publication Date 1/26/2016
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 12
Name:Mitogen-activated protein kinase 12
Synonyms:ERK6 | MAP kinase p38 gamma | MAPK12 | MK12_HUMAN | Mitogen-activated protein kinase 12 (MAPK12 p38 gamma) | Mitogen-activated protein kinase 12 (p38 gamma) | Mitogen-activated protein kinase 12 Gamma | Mitogen-activated protein kinase p38 gamma (p38 MAPKγ) | SAPK3 | p38 delta/gamma
Type:Protein
Mol. Mass.:41938.69
Organism:Homo sapiens (Human)
Description:P53778
Residue:367
Sequence:
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
VSKETPL
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BDBM142598
n/a
NameBDBM142598
Synonyms:US10238658, Example Reference | US10813932, Reference Compound | US8933228, Ref 2 | US9242960, 1 | US9249125, Reference Compound | US9701670, Reference Compound | US9724347, Example Reference | US9993478, Example Reference
TypeSmall organic molecule
Emp. Form.C33H34N6O4
Mol. Mass.578.6609
SMILESCOCC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c3ccccc23)ccn1
Structure
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