Reaction Details |
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Target | RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E] |
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Ligand | BDBM202729 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Enzyme Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 0.056±n/a nM |
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Comments | extracted |
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Citation | Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Biaryl amide compounds as kinase inhibitors US Patent US9242969 Publication Date 1/26/2016 |
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More Info.: | Get all data from this article, Assay Method |
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RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E] |
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Name: | RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E] |
Synonyms: | C-RAF | Proto-oncogene C-Raf (C-Raf FL) | RAF | RAF proto-oncogene serine/threonine-protein kinase | RAF1 | RAF1_HUMAN |
Type: | n/a |
Mol. Mass.: | 73012.38 |
Organism: | Homo sapiens (Human) |
Description: | P04049[Y340E,Y341E] |
Residue: | 648 |
Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSEEWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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BDBM202729 |
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n/a |
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Name | BDBM202729 |
Synonyms: | US10245267, Example 75 | US10709712, Example 75 | US9242969, 75 | US9694016, 75 |
Type | Small organic molecule |
Emp. Form. | C24H23F2N3O2 |
Mol. Mass. | 423.4551 |
SMILES | Cc1ccc(NC(=O)c2cccc(c2)C(F)F)cc1-c1ccnc(c1)N1CCOCC1 |
Structure |
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