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TargetRAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E]
LigandBDBM202729
Substrate/Competitorn/a
Meas. Tech.In Vitro Enzyme Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 0.056±n/a nM
Commentsextracted
Citation Barsanti, PABurger, MLou, YNishiguchi, GPolyakov, VRamurthy, SRico, ASetti, LSmith, ATaft, BTanner, HDiPesa, AYusuff, N Biaryl amide compounds as kinase inhibitors US Patent US9242969 Publication Date 1/26/2016
More Info.:Get all data from this article,  Assay Method
 
RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E]
Name:RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E]
Synonyms:C-RAF | Proto-oncogene C-Raf (C-Raf FL) | RAF | RAF proto-oncogene serine/threonine-protein kinase | RAF1 | RAF1_HUMAN
Type:n/a
Mol. Mass.:73012.38
Organism:Homo sapiens (Human)
Description:P04049[Y340E,Y341E]
Residue:648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSEEWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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BDBM202729
n/a
NameBDBM202729
Synonyms:US10245267, Example 75 | US10709712, Example 75 | US9242969, 75 | US9694016, 75
TypeSmall organic molecule
Emp. Form.C24H23F2N3O2
Mol. Mass.423.4551
SMILESCc1ccc(NC(=O)c2cccc(c2)C(F)F)cc1-c1ccnc(c1)N1CCOCC1
Structure
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