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TargetRAF proto-oncogene serine/threonine-protein kinase [1-324]
LigandBDBM202699
Substrate/Competitorn/a
Meas. Tech.In Vitro Enzyme Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 1.018±n/a nM
Commentsextracted
Citation Barsanti, PABurger, MLou, YNishiguchi, GPolyakov, VRamurthy, SRico, ASetti, LSmith, ATaft, BTanner, HDiPesa, AYusuff, N Biaryl amide compounds as kinase inhibitors US Patent US9242969 Publication Date 1/26/2016
More Info.:Get all data from this article,  Assay Method
 
RAF proto-oncogene serine/threonine-protein kinase [1-324]
Name:RAF proto-oncogene serine/threonine-protein kinase [1-324]
Synonyms:C-Raf TR (aa 1-324) | Proto-oncogene C-Raf (C-Raf TR) | RAF | RAF1 | RAF1_HUMAN
Type:n/a
Mol. Mass.:36996.69
Organism:Homo sapiens (Human)
Description:P04049 (1-324)
Residue:324
Sequence:
QEKNKIRPRGQRDSSEEWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTP
EQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQ
LIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQ
PTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRG
YASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPS
LHRAAHTEDINACTLTTSPRLPVF
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BDBM202699
n/a
NameBDBM202699
Synonyms:US10245267, Example 45 | US10709712, Example 45 | US9242969, 45 | US9694016, 45
TypeSmall organic molecule
Emp. Form.C26H27F3N4O2
Mol. Mass.484.5134
SMILESCC(C)c1cc(nc(n1)N1CCOCC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Structure
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