| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM50040790 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IRAK4 Inhibition Assay |
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| pH | 7.2±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.8±n/a nM |
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| Comments | extracted |
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| Citation |  Paidi, VR; Kumar, SR; Banerjee, A; Sistla, R; Nair, SK; Pitts, WJ; Hynes, J Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors US Patent US9242975 Publication Date 1/26/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM50040790 |
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| n/a |
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| Name | BDBM50040790 |
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| Synonyms: | CHEMBL3353197 | US10227340, Example 27 | US9242975, 27 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N6OS2 |
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| Mol. Mass. | 438.569 |
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| SMILES | CNC(=O)c1nc(sc1C)-c1cnc(Nc2ccc3ncsc3c2)cc1NC(C)C |
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| Structure | 
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