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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM203518
Substrate/Competitorn/a
Meas. Tech.IMAP technology (Molecular Devices)
pH7.2±n/a
Temperature298.15±n/a K
IC50 2.5±n/a nM
Commentsextracted
Citation Seganish, WMBrumfield, SNLim, JMatasi, JJMcElroy, WTTulshian, DBLavey, BJAltman, MDGibeau, CRLampe, JWMethot, JZhu, L Aminopyrimidinones as interleukin receptor-associated kinase inhibitors US Patent US9221809 Publication Date 12/29/2015
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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  Blast E-value cutoff:
BDBM203518
n/a
NameBDBM203518
Synonyms:US9221809, 55
TypeSmall organic molecule
Emp. Form.C20H24N6O4S
Mol. Mass.444.507
SMILESOC[C@H]1C[C@@H](Nc2nc(NC3CCC3)[nH]c(=O)c2-c2nc3cnccc3s2)[C@H](O)[C@@H]1O |r|
Structure
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