| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase WNK1 [1-491] |
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| Ligand | BDBM203827 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In vitro OSR1 Phosphorylation Assay (OSR1) |
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| pH | 7.3±n/a |
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| Temperature | 277.15±n/a K |
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| IC50 | 41±0.0 nM |
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| Comments | extracted |
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| Citation |  Yamada, K; Park, HM; Rigel, DF; DiPetrillo, K; Whalen, EJ; Anisowicz, A; Beil, M; Berstler, J; Brocklehurst, CE; Burdick, DA; Caplan, SL; Capparelli, MP; Chen, G; Chen, W; Dale, B; Deng, L; Fu, F; Hamamatsu, N; Harasaki, K; Herr, T; Hoffmann, P; Hu, QY; Huang, WJ; Idamakanti, N; Imase, H; Iwaki, Y; Jain, M; Jeyaseelan, J; Kato, M; Kaushik, VK; Kohls, D; Kunjathoor, V; LaSala, D; Lee, J; Liu, J; Luo, Y; Ma, F; Mo, R; Mowbray, S; Mogi, M; Ossola, F; Pandey, P; Patel, SJ; Raghavan, S; Salem, B; Shanado, YH; Trakshel, GM; Turner, G; Wakai, H; Wang, C; Weldon, S; Wielicki, JB; Xie, X; Xu, L; Yagi, YI; Yasoshima, K; Yin, J; Yowe, D; Zhang, JH; Zheng, G; Monovich, L Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat Chem Biol12:896-898 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase WNK1 [1-491] |
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| Name: | Serine/threonine-protein kinase WNK1 [1-491] |
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| Synonyms: | HSN2 | KDP | KIAA0344 | PRKWNK1 | WNK1 | WNK1_HUMAN | With-No-Lysine (K) Kinase 1 (WNK1) | With-No-Lysine kinase 1 (WNK1) |
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| Type: | n/a |
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| Mol. Mass.: | 53757.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H4A3 (1-491aa). Carna Biosciences, cat no. 05-179 |
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| Residue: | 491 |
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| Sequence: | MSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGAAAADAVTGRTEEYRRRRHT
MDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPH
REETVTATATSQVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPP
ARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLD
TETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLV
TELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGP
TGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEY
PYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQ
EETGVRVELAE
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| BDBM203827 |
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| n/a |
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| Name | BDBM203827 |
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| Synonyms: | N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-oxadiazol- 2-yl)pyridin-2-yl)piperidin-4-yl)-1H-imidazole-5-carboxamide | WNK463 | WNK463 (2) |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25F3N6O2 |
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| Mol. Mass. | 462.4681 |
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| SMILES | CC(C)(C)NC(=O)c1cncn1C1CCN(CC1)c1ccc(cc1)-c1nnc(o1)C(F)(F)F |
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| Structure | 
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