| Reaction Details |
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 | Report a problem with these data |
| Target | DNA-(apurinic or apyrimidinic site) endonuclease |
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| Ligand | BDBM203861 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence-Based APE1 Endonuclease Activity Assay |
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| pH | 7.5±n/a |
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| IC50 | 2.5e+2± 1e+1 nM |
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| Comments | extracted |
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| Citation |  Guerreiro, PS; Estácio, SG; Antunes, F; Fernandes, AS; Pinheiro, PF; Costa, JG; Castro, M; Miranda, JP; Guedes, RC; Oliveira, NG Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1. Chem Biol Drug Des88:915-925 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA-(apurinic or apyrimidinic site) endonuclease |
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| Name: | DNA-(apurinic or apyrimidinic site) endonuclease |
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| Synonyms: | APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1 |
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| Type: | Protein |
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| Mol. Mass.: | 35560.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27695 |
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| Residue: | 318 |
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| Sequence: | MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL
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| BDBM203861 |
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| n/a |
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| Name | BDBM203861 |
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| Synonyms: | (5-(acetylamino)-2-[2-(4-isothiocyanato-3-sulfophenyl)ethenyl] benzenesulfonic acid disodium salt (Compound 22) | NSC 378144 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12N2O7S3 |
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| Mol. Mass. | 452.482 |
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| SMILES | CC(=O)Nc1ccc(\C=C\c2ccc(N=C=S)c(c2)S([O-])(=O)=O)c(c1)S([O-])(=O)=O |
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| Structure | 
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