Ki Summary

Reaction Details

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Target

Complement factor D [24-253]

Ligand

BDBM171272

Substrate/Competitor

n/a

Meas. Tech.

Complement FD Thioesterolysis Assay

7.5±n/a

Temperature

298.15±n/a K

IC50

8.6e+2± 1e+1 nM

Comments

extracted

Citation

Maibaum, J; Liao, SM; Vulpetti, A; Ostermann, N; Randl, S; R�disser, S; Lorthiois, E; Erbel, P; Kinzel, B; Kolb, FA; Barbieri, S; Wagner, J; Durand, C; Fettis, K; Dussauge, S; Hughes, N; Delgado, O; Hommel, U; Gould, T; Mac Sweeney, A; Gerhartz, B; Cumin, F; Flohr, S; Schubart, A; Jaffee, B; Harrison, R; Risitano, AM; Eder, J; Anderson, K Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat Chem Biol12:1105-1110 (2016) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Complement factor D [24-253]

Name:

Complement factor D [24-253]

Synonyms:

Adn | CFAD_MOUSE | Cfd | Complement factor D (FD) catalytic domain (Mouse fD) | Df

Type:

Protein

Mol. Mass.:

25065.53

Organism:

Mus musculus (Mouse)

Description:

P03953 (24-253 aa); 5FCR

Residue:

230

Sequence:

GRILGGQEAAAHARPYMASVQVNGTHVCGGTLLDEQWVLSAAHCMDGVTDDDSVQVLLGA
HSLSAPEPYKRWYDVQSVVPHPGSRPDSLEDDLILFKLSQNASLGPHVRPLPLQYEDKEV
EPGTLCDVAGWGVVTHAGRRPDVLHQLRVSIMNRTTCNLRTYHDGVVTINMMCAESNRRD
TCRGDSGSPLVCGDAVEGVVTWGSRVCGNGKKPGVYTRVSSYRMWIENIT

BDBM171272

n/a

Name

BDBM171272

Synonyms:

1-(2-((1R,3S,5R)-3-(((R)-1-(3-Chloro-2-fluorophenyl)ethyl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (6) | US9085555, 702

Type

Small organic molecule

Emp. Form.

C23H22ClFN6O3

Mol. Mass.

484.911

SMILES

C[C@@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12)c1cccc(Cl)c1F |r|

Structure