Reaction Details |
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Target | Kallikrein-7 [37-253,Y180R] |
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Ligand | BDBM171350 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Human KLK7 Fluorescence-Lifetime Assay |
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pH | 5.6±n/a |
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Temperature | 298.15±n/a K |
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IC50 | >1.00e+5±n/a nM |
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Comments | extracted |
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Citation | Maibaum, J; Liao, SM; Vulpetti, A; Ostermann, N; Randl, S; Rüdisser, S; Lorthiois, E; Erbel, P; Kinzel, B; Kolb, FA; Barbieri, S; Wagner, J; Durand, C; Fettis, K; Dussauge, S; Hughes, N; Delgado, O; Hommel, U; Gould, T; Mac Sweeney, A; Gerhartz, B; Cumin, F; Flohr, S; Schubart, A; Jaffee, B; Harrison, R; Risitano, AM; Eder, J; Anderson, K Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat Chem Biol12:1105-1110 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kallikrein-7 [37-253,Y180R] |
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Name: | Kallikrein-7 [37-253,Y180R] |
Synonyms: | KLK7 | KLK7_HUMAN | Kalligrein-7 Y180R (KLK7) | PRSS6 | SCCE |
Type: | Protein |
Mol. Mass.: | 23785.70 |
Organism: | Homo sapiens (Human) |
Description: | P49862 (37-253 aa with Y180R mutation) |
Residue: | 217 |
Sequence: | ARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKAS
KSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPD
VTFPSDLMCVDVKLISPQDCTKVRKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQ
GLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
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BDBM171350 |
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n/a |
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Name | BDBM171350 |
Synonyms: | 1-(2-((1R,3S,5R)-3-((6-Bromopyridin-2-yl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H-indazole-3-carboxamide (7) | US9085555, 727 |
Type | Small organic molecule |
Emp. Form. | C21H19BrN6O3 |
Mol. Mass. | 483.318 |
SMILES | NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccccc12 |
Structure |
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