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TargetKallikrein-7 [37-253,Y180R]
LigandBDBM171350
Substrate/Competitorn/a
Meas. Tech.Human KLK7 Fluorescence-Lifetime Assay
pH5.6±n/a
Temperature298.15±n/a K
IC50>1.00e+5±n/a nM
Commentsextracted
Citation Maibaum, JLiao, SMVulpetti, AOstermann, NRandl, SRüdisser, SLorthiois, EErbel, PKinzel, BKolb, FABarbieri, SWagner, JDurand, CFettis, KDussauge, SHughes, NDelgado, OHommel, UGould, TMac Sweeney, AGerhartz, BCumin, FFlohr, SSchubart, AJaffee, BHarrison, RRisitano, AMEder, JAnderson, K Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat Chem Biol12:1105-1110 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kallikrein-7 [37-253,Y180R]
Name:Kallikrein-7 [37-253,Y180R]
Synonyms:KLK7 | KLK7_HUMAN | Kalligrein-7 Y180R (KLK7) | PRSS6 | SCCE
Type:Protein
Mol. Mass.:23785.70
Organism:Homo sapiens (Human)
Description:P49862 (37-253 aa with Y180R mutation)
Residue:217
Sequence:
ARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKAS
KSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPD
VTFPSDLMCVDVKLISPQDCTKVRKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQ
GLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
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  Blast E-value cutoff:
BDBM171350
n/a
NameBDBM171350
Synonyms:1-(2-((1R,3S,5R)-3-((6-Bromopyridin-2-yl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1H-indazole-3-carboxamide (7) | US9085555, 727
TypeSmall organic molecule
Emp. Form.C21H19BrN6O3
Mol. Mass.483.318
SMILESNC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccccc12
Structure
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