| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Ligand | BDBM203873 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Binding A |
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| pH | 7.4±n/a |
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| Temperature | 297.15±n/a K |
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| Ki | 44±0 nM |
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| IC50 | 162±23 nM |
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| Comments | extracted |
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| Citation |  Akçay, G; Belmonte, MA; Aquila, B; Chuaqui, C; Hird, AW; Lamb, ML; Rawlins, PB; Su, N; Tentarelli, S; Grimster, NP; Su, Q Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain. Nat Chem Biol12:931-936 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Synonyms: | BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 17896.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820[171-327] |
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| Residue: | 157 |
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| Sequence: | EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
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| BDBM203873 |
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| n/a |
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| Name | BDBM203873 |
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| Synonyms: | 7-(3-((4-Boronophenoxy)methyl)-1,5-dimethyl-1H-pyrazol-4-yl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid, 9 | Mcl-1 inhibitor 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H38BN3O6 |
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| Mol. Mass. | 595.493 |
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| SMILES | CC1C(C(COc2ccc(cc2)B(O)O)NN1C)c1cccc2C(CCCOc3cccc4ccccc34)C(Nc12)C(O)=O |
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| Structure | 
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