Reaction Details |
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Target | Mitogen-activated protein kinase 1 |
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Ligand | BDBM204458 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ERK2 (20 pM) Kinase Assay |
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pH | 7.5±n/a |
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IC50 | 0.0187±n/a nM |
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Comments | extracted |
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Citation | Bagdanoff, JT; Ding, Y; Han, W; Huang, Z; Jiang, Q; Jin, JX; Kou, X; Lee, P; Lindvall, M; Min, Z; Pan, Y; Pecchi, S; Pfister, KB; Poon, D; Rauniyar, V; Wang, XM; Zhang, Q; Zhou, J; Zhu, S Aminoheteroaryl benzamides as kinase inhibitors US Patent US9242996 Publication Date 1/26/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 1 |
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Name: | Mitogen-activated protein kinase 1 |
Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
Type: | Ser/Thr Protein Kinase |
Mol. Mass.: | 41392.76 |
Organism: | Homo sapiens (Human) |
Description: | P28482 |
Residue: | 360 |
Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM204458 |
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n/a |
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Name | BDBM204458 |
Synonyms: | US9242996, 133 |
Type | Small organic molecule |
Emp. Form. | C25H23ClFN5O2 |
Mol. Mass. | 479.934 |
SMILES | Cc1c(cnn1C)-c1cnc(N)c(c1)-c1ccc(C(=O)N[C@H](CO)c2cccc(Cl)c2)c(F)c1 |
Structure |
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