Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase 1

Ligand

BDBM204270

Substrate/Competitor

n/a

Meas. Tech.

ERK2 (20 pM) Kinase Assay

7.5±n/a

IC50

0.00977±n/a nM

Comments

extracted

Citation

Bagdanoff, JT; Ding, Y; Han, W; Huang, Z; Jiang, Q; Jin, JX; Kou, X; Lee, P; Lindvall, M; Min, Z; Pan, Y; Pecchi, S; Pfister, KB; Poon, D; Rauniyar, V; Wang, XM; Zhang, Q; Zhou, J; Zhu, S Aminoheteroaryl benzamides as kinase inhibitors US Patent US9242996 Publication Date 1/26/2016

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 1

Name:

Mitogen-activated protein kinase 1

Synonyms:

Type:

Ser/Thr Protein Kinase

Mol. Mass.:

41392.76

Organism:

Homo sapiens (Human)

Description:

P28482

Residue:

360

Sequence:

MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS

BDBM204270

n/a

Name

BDBM204270

Synonyms:

US9242996, 344

Type

Small organic molecule

Emp. Form.

C25H25F2IN4O3

Mol. Mass.

594.3923

SMILES

Nc1ncc(nc1-c1ccc(C(=O)N[C@H](CO)c2cc(F)cc(I)c2)c(F)c1)[C@H]1CC[C@H](O)CC1 |r,wU:31.34,wD:28.30,14.14,(-6.67,3.85,;-6.67,2.31,;-8,1.54,;-8,,;-6.67,-.77,;-5.33,,;-5.33,1.54,;-4,2.31,;-2.67,1.54,;-1.33,2.31,;-1.33,3.85,;,4.62,;,6.16,;1.33,3.85,;2.67,4.62,;2.67,6.16,;4,6.93,;4,3.85,;5.33,4.62,;6.67,3.85,;8,4.62,;6.67,2.31,;5.33,1.54,;5.33,,;4,2.31,;-2.67,4.62,;-2.67,6.16,;-4,3.85,;-6.67,-2.31,;-8,-3.08,;-8,-4.62,;-6.67,-5.39,;-6.67,-6.93,;-5.33,-4.62,;-5.33,-3.08,)|

Structure