Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase 1

Ligand

BDBM204302

Substrate/Competitor

n/a

Meas. Tech.

ERK2 (20 pM) Kinase Assay

7.5±n/a

IC50

0.0209±n/a nM

Comments

extracted

Citation

Bagdanoff, JT; Ding, Y; Han, W; Huang, Z; Jiang, Q; Jin, JX; Kou, X; Lee, P; Lindvall, M; Min, Z; Pan, Y; Pecchi, S; Pfister, KB; Poon, D; Rauniyar, V; Wang, XM; Zhang, Q; Zhou, J; Zhu, S Aminoheteroaryl benzamides as kinase inhibitors US Patent US9242996 Publication Date 1/26/2016

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 1

Name:

Mitogen-activated protein kinase 1

Synonyms:

Type:

Ser/Thr Protein Kinase

Mol. Mass.:

41392.76

Organism:

Homo sapiens (Human)

Description:

P28482

Residue:

360

Sequence:

MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS

BDBM204302

n/a

Name

BDBM204302

Synonyms:

US9242996, 381

Type

Small organic molecule

Emp. Form.

C26H29BrFN5O2

Mol. Mass.

542.443

SMILES

CNC[C@@H](NC(=O)c1ccc(cc1F)-c1nc(cnc1N)[C@H]1CC[C@H](O)CC1)c1cccc(Br)c1 |r,wU:21.22,wD:3.3,24.26,(6,6.16,;4.67,6.93,;3.33,6.16,;3.33,4.62,;2,3.85,;.67,4.62,;.67,6.16,;-.67,3.85,;-.67,2.31,;-2,1.54,;-3.33,2.31,;-3.33,3.85,;-2,4.62,;-2,6.16,;-4.67,1.54,;-4.67,,;-6,-.77,;-7.34,,;-7.34,1.54,;-6,2.31,;-6,3.85,;-6,-2.31,;-4.67,-3.08,;-4.67,-4.62,;-6,-5.39,;-6,-6.93,;-7.34,-4.62,;-7.34,-3.08,;4.67,3.85,;6,4.62,;7.34,3.85,;7.34,2.31,;6,1.54,;6,,;4.67,2.31,)|

Structure