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TargetMitogen-activated protein kinase 14
LigandBDBM205336
Substrate/Competitorn/a
Meas. Tech.p38 MAPKα Enzyme Inhibition Assay
IC50 47±n/a nM
Citation Duffy, LAKing-Underwood, JLongshaw, AIMurray, PJOnions, STTaddei, DMWilliams, JGIto, KCharron, CE Pyrazole derivatives as p38 MAP inhibitors US Patent US9249125 Publication Date 2/2/2016
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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  Blast E-value cutoff:
BDBM205336
n/a
NameBDBM205336
Synonyms:US9249125, 89
TypeSmall organic molecule
Emp. Form.C41H43N11O4
Mol. Mass.753.8514
SMILESCc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(=O)n(CCN5CCOCC5)c4)C(C)(C)C)c4ccccc34)n2)cc2cn[nH]c12
Structure
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