| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [333-460] |
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| Ligand | BDBM205453 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Bromodomains Assay for DiscoveRx Gene Symbol |
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| Ki | 0.053±0.0 nM |
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| Citation |  Tanaka, M; Roberts, JM; Seo, HS; Souza, A; Paulk, J; Scott, TG; DeAngelo, SL; Dhe-Paganon, S; Bradner, JE Design and characterization of bivalent BET inhibitors. Nat Chem Biol12:1089-1096 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [333-460] |
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| Name: | Bromodomain-containing protein 4 [333-460] |
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| Synonyms: | BET bromodomain 4(2) (BRD4(2)) | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | HUNK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 14818.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa (333-460) |
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| Residue: | 128 |
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| Sequence: | KDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCD
IIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEM
RFAKMPDE
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| BDBM205453 |
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| n/a |
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| Name | BDBM205453 |
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| Synonyms: | MTI (35) |
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| Type | Small organic molecule |
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| Emp. Form. | C54H66Cl2N10O9S2 |
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| Mol. Mass. | 1134.199 |
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| SMILES | Cc1sc-2c(c1C)C(=NC(CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C[C@@H]1N=C(c3c(C)c(C)sc3-n3c(C)nnc13)c1ccc(Cl)cc1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8,43| |
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| Structure | 
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