| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [44-168,333-460] |
|---|
| Ligand | BDBM205433 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | BROMOscan Assay |
|---|
| Kd | 0.0075±0.0 nM |
|---|
| Citation |  Tanaka, M; Roberts, JM; Seo, HS; Souza, A; Paulk, J; Scott, TG; DeAngelo, SL; Dhe-Paganon, S; Bradner, JE Design and characterization of bivalent BET inhibitors. Nat Chem Biol12:1089-1096 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain-containing protein 4 [44-168,333-460] |
|---|
| Name: | Bromodomain-containing protein 4 [44-168,333-460] |
|---|
| Synonyms: | BET bromodomain 4(1,2) (BRD4(1,2)) | BRD4 | BRD4_HUMAN | HUNK1 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 29666.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60885 (BRD4, 44-168 and 333-460) |
|---|
| Residue: | 253 |
|---|
| Sequence: | NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE
LPTEEKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGL
HDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQ
DVFEMRFAKMPDE
|
|
|
|---|
| BDBM205433 |
|---|
| n/a |
|---|
| Name | BDBM205433 |
|---|
| Synonyms: | (6S+2S)-PEG3 (9) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C47H50Cl2N10O7S2 |
|---|
| Mol. Mass. | 1001.999 |
|---|
| SMILES | COC(=O)C[C@@H]1N=C(c2c(C)c(sc2-n2c(C)nnc12)C(=O)NCCOCCOCCOCCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)c1ccc(Cl)cc1 |r,c:6,42| |
|---|
| Structure | 
|
|---|
Search and Browse
