Reaction Details |
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Target | Bromodomain-containing protein 4 [44-168] |
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Ligand | BDBM205430 |
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Substrate/Competitor | n/a |
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Meas. Tech. | AlphaScreen BRD Binding Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 3.58±0.0 nM |
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Comments | extracted |
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Citation | Tanaka, M; Roberts, JM; Seo, HS; Souza, A; Paulk, J; Scott, TG; DeAngelo, SL; Dhe-Paganon, S; Bradner, JE Design and characterization of bivalent BET inhibitors. Nat Chem Biol12:1089-1096 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bromodomain-containing protein 4 [44-168] |
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Name: | Bromodomain-containing protein 4 [44-168] |
Synonyms: | BET bromodomain 4(1) (BRD4(1)) | BRD4 | BRD4-BD1 protein (aa 44-168) | BRD4_HUMAN | Bromodomain protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4) (aa 44-168) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 bromodomain 1 (BRD4-BD1) | HUNK1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 14866.49 |
Organism: | Homo sapiens (Human) |
Description: | aa (44-168) |
Residue: | 125 |
Sequence: | NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE
LPTEE
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BDBM205430 |
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n/a |
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Name | BDBM205430 |
Synonyms: | (6S+2S)-PEG0 (6) |
Type | Small organic molecule |
Emp. Form. | C41H38Cl2N10O4S2 |
Mol. Mass. | 869.841 |
SMILES | COC(=O)C[C@@H]1N=C(c2c(C)c(sc2-n2c(C)nnc12)C(=O)NCCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)c1ccc(Cl)cc1 |r,c:6,33| |
Structure |
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