| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 [18-604,R106Q] |
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| Ligand | BDBM17638 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | COX Enzyme Inhibition Assay (Table 2) |
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| IC50 | 3.0e+2±n/a nM |
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| Citation |  Uddin, MJ; Crews, BC; Xu, S; Ghebreselasie, K; Daniel, CK; Kingsley, PJ; Banerjee, S; Marnett, LJ Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors. ACS Chem Biol11:3052-3060 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 2 [18-604,R106Q] |
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| Name: | Prostaglandin G/H synthase 2 [18-604,R106Q] |
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| Synonyms: | Cox-2 | Cox2 | Cyclooxygenase-2 mutant (R120Q) | PGH2_MOUSE | Pghs-b | Ptgs2 | Tis10 |
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| Type: | Protein |
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| Mol. Mass.: | 67231.13 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Sequence based on 4OTJ |
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| Residue: | 587 |
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| Sequence: | ANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYI
LTHFKGVWNIVNNIPFLRSLIMKYVLTSQSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRA
LPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFK
TDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQV
EMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQT
SRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLL
PDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKAS
IDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEK
PRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNN
VKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRRSTEL
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| BDBM17638 |
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| n/a |
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| Name | BDBM17638 |
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| Synonyms: | 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid | CHEMBL6 | Indocin | Indomethacin | US11478464, Compound Indomethacin | US11786535, Compound Indomethacin | US9271961, Indomethacin | indometacin |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16ClNO4 |
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| Mol. Mass. | 357.788 |
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| SMILES | COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1 |
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| Structure | 
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