| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Ligand | BDBM27566 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 320±n/a nM |
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| Citation |  Zhang, A; Miao, Z; Ye, N; Huan, X; Song, Z; Chen, C; Chen, Y; Ding, J Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors US Patent US9255106 Publication Date 2/9/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Name: | Protein mono-ADP-ribosyltransferase PARP3 [R100H] |
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| Synonyms: | (ARTD3 or PARP3) | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT3 | ADPRTL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3) | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly [ADP-ribose] polymerase 3 (PARP-3) | Poly(ADP-ribose) polymerase-3 (ARTD3/PARP3) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60071.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y6F1[R100H] |
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| Residue: | 533 |
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| Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
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| BDBM27566 |
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| n/a |
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| Name | BDBM27566 |
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| Synonyms: | 4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one | Acylpiperazine analogue, 47 | Olaparib | US10174023, AZD2281 | US10597399, Compound AZD2281 | US9187430, AZD-2281 | US9255106, AZD2281 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23FN4O3 |
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| Mol. Mass. | 434.4628 |
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| SMILES | Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCN(CC1)C(=O)C1CC1 |
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| Structure | 
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