| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
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| Ligand | BDBM120092 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ERK-2 Enzymatic Assay |
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| pH | 7.3±n/a |
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| IC50 | 15.6±n/a nM |
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| Comments | extracted |
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| Citation |  Blake, JF; Chicarelli, MJ; Garrey, RF; Gaudino, J; Grina, J; Moreno, DA; Mohr, PJ; Ren, L; Schwarz, J; Chen, H; Robarge, K; Zhou, A Serine/threonine kinase inhibitors US Patent US9259470 Publication Date 2/16/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 1 |
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| Name: | Mitogen-activated protein kinase 1 |
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| Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
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| Type: | Ser/Thr Protein Kinase |
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| Mol. Mass.: | 41392.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28482 |
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| Residue: | 360 |
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| Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM120092 |
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| n/a |
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| Name | BDBM120092 |
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| Synonyms: | US8697715, 14 | US9259470, 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClFN5O3 |
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| Mol. Mass. | 445.875 |
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| SMILES | OCC(c1ccc(Cl)c(F)c1)n1ccc(nc1=O)-c1ccnc(NC2CCOCC2)n1 |
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| Structure | 
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