| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase WNK2 [166-489] |
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| Ligand | BDBM207990 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | WNK In Vitro Radiometric Assays |
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| pH | 7.3±n/a |
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| IC50 | 50±n/a nM |
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| Comments | extracted |
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| Citation |  Yamada, K; Zhang, JH; Xie, X; Reinhardt, J; Xie, AQ; LaSala, D; Kohls, D; Yowe, D; Burdick, D; Yoshisue, H; Wakai, H; Schmidt, I; Gunawan, J; Yasoshima, K; Yue, QK; Kato, M; Mogi, M; Idamakanti, N; Kreder, N; Drueckes, P; Pandey, P; Kawanami, T; Huang, W; Yagi, YI; Deng, Z; Park, HM Discovery and Characterization of Allosteric WNK Kinase Inhibitors. ACS Chem Biol11:3338-3346 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase WNK2 [166-489] |
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| Name: | Serine/threonine-protein kinase WNK2 [166-489] |
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| Synonyms: | KIAA1760 | PRKWNK2 | SDCCAG43 | WNK2 | WNK2_HUMAN | With-No-Lysine kinase 2 (WNK2) |
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| Type: | Protein |
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| Mol. Mass.: | 37413.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | WNK2 truncation (166-489 aa) |
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| Residue: | 324 |
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| Sequence: | GRTRRDEPEEEEDDEDDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETWVEVAWCE
LQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKT
YLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGL
ATLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQI
YRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDTGVRVELAE
EDHGRKSTIALRLWVEDPKKLKGK
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| BDBM207990 |
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| n/a |
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| Name | BDBM207990 |
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| Synonyms: | (2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)thiazol-4-yl)indolin-1-yl)methanone (Compound 2) |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22ClN3O2S |
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| Mol. Mass. | 475.99 |
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| SMILES | CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1OCc1ccc(Cl)cc1 |
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| Structure | 
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