| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-protein thioesterase 1 [Q83P] |
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| Ligand | BDBM207991 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Steady-State Kinetic Assays |
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| pH | 6.5±n/a |
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| Ki | 370±20 nM |
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| Comments | extracted |
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| Citation |  Won, SJ; Davda, D; Labby, KJ; Hwang, SY; Pricer, R; Majmudar, JD; Armacost, KA; Rodriguez, LA; Rodriguez, CL; Chong, FS; Torossian, KA; Palakurthi, J; Hur, ES; Meagher, JL; Brooks, CL; Stuckey, JA; Martin, BR Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol11:3374-3382 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-protein thioesterase 1 [Q83P] |
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| Name: | Acyl-protein thioesterase 1 [Q83P] |
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| Synonyms: | APT1 | Acyl-protein thioesterase 1 (APT1 Q83P) | LPL1 | LYPA1_HUMAN | LYPLA1 |
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| Type: | Protein |
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| Mol. Mass.: | 24639.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human APT1 with Q83P mutation |
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| Residue: | 230 |
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| Sequence: | MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRP
VTLNMNVAMPSWFDIIGLSPDSPEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLM
FGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
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| BDBM207991 |
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| n/a |
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| Name | BDBM207991 |
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| Synonyms: | ML348 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17ClF3N3O3 |
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| Mol. Mass. | 415.794 |
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| SMILES | FC(F)(F)c1ccc(Cl)c(NC(=O)CN2CCN(CC2)C(=O)c2ccco2)c1 |
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| Structure | 
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